“Obesity leads to cognitive impairment by activating microglial cells, which consume otherwise functional synapses in the hippocampus, according to a study of male mice published in JNeurosci.”
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Elise C. Cope, Elizabeth A. LaMarca, Patrick K. Monari, Lyra B. Olson, Susana Martinez, Anna D. Zych, Nicole J. Katchur, Elizabeth Gould. Microglia play an active role in obesity-associated cognitive decline. The Journal of Neuroscience, 2018; 0789-18 DOI: 10.1523/JNEUROSCI.0789-18.2018