“In this Review, we examine the influence that the gut microbiota have on immune function via modulation of serotonin production in the gut and through complex interactions with components of […]
Category: Neuroscience
Scientists identify gut-derived metabolites that play a role in neurodegeneration (2021)
“Our findings suggest that MS patients’ gut bacteria produce and release large amounts p-cresol-sulfate, indoxyl-sulfate and N-phenylacetylglutamine into the bloodstream, and they eventually reach the cerebrospinal fluid,” said Hye-Jin Park, […]
New evidence hints at the role of gut microbiota in autistic spectrum disorder
“recent neuroscience studies have found that the biological makeup of the gut could contribute to some of the most characteristic symptoms of ASD. More specifically, experiments on mice suggest that […]
Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders
“Collectively, these results show for the first time that glyphosate infiltrates the brain, elevates both the expression of TNFα and soluble Aβ, and disrupts the transcriptome in a dose-dependent manner, […]
The serotonin theory of depression: a systematic umbrella review of the evidence
“The main areas of serotonin research provide no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by […]
Blood-brain barrier breakdown is an early biomarker for human cognitive dysfunction (2019)
Our data show that individuals with early cognitive dysfunction develop brain capillary damage and BBB breakdown in the hippocampus irrespective of Alzheimer’s Aβ and/or tau biomarker changes, suggesting that BBB […]
Vagus nerve stimulation promotes resolution of inflammation
“The findings indicate that electrical signals in the vagus nerve activate a cholinergic signal promoting Alox15-dependent lipid mediator biosynthesis and accelerating resolution of inflammation, providing additional insights into neural regulation […]
Decoding a direct dialog between the gut microbiota and the brain
“It is extraordinary to discover that bacterial fragments act directly on a brain center as strategic as the hypothalamus, which is known to manage vital functions such as body temperature, […]
Study identifies how Epstein-Barr virus triggers multiple sclerosis
“Part of the EBV protein mimics your own host protein—in this case, GlialCAM, found in the insulating sheath on nerves,” said William Robinson, MD, Ph.D., professor of immunology and rheumatology […]
Vitamin D, Epstein-Barr virus, and endogenous retroviruses in multiple sclerosis – facts and hypotheses (2021)
“Here, we summarize the important data on vitamin D, including polymorphisms in genes related to vitamin D metabolism, EBV and ERV, in the pathogenesis of MS and create hypotheses regarding […]