Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression
Exposing newborn mice to low-dose penicillin led to substantial changes in intestinal microbiota population structure and composition. Transcriptomic alterations implicate pathways perturbed in neurodevelopmental and neuropsychiatric disorders. There also were substantial effects on frontal cortex and amygdala gene expression by bioinformatic interrogation, affecting multiple pathways underlying neurodevelopment.
“we have obtained brain tissues from a Colombian cohort of donors with familial Alzheimer’s disease. We have used established methods to measure the aluminum content of these tissues and we have compared the data with a recently measured dataset for control brain tissues. We report significantly higher levels of aluminum in brain tissues in donors […]
Researchers at Johns Hopkins found evidence of rises in the bloodstream levels of toxicants known to be stored long term in fat, including PCBs & organochlorine pesticides.
“It isn’t only a story of ‘[metal] exposure leads to bad outcomes’ — it’s also a story of how different metabolic profiles may make certain people more vulnerable,”
“Studies in humans highlight the potential contribution of propionate in the diet to the development of insulin resistance and obesity.”
“Over 50% of trials published in top psychiatry/psychology journals contain spin in the abstract.”
“In this prospective birth cohort study, fluoride exposure during pregnancy was associated with lower IQ scores in children aged 3 to 4 years.”
“Food scientists have shown that feeding frying oil to mice exaggerated colonic inflammation, enhanced tumor growth and worsened gut leakage, spreading bacteria or toxic bacterial products into the bloodstream.”
“the UCF scientists discovered how high levels of Propionic Acid (PPA), used to increase the shelf life of packaged foods and inhibit mold in commercially processed cheese and bread, reduce the development of neurons in fetal brains.”
“I would strongly advise that users should not use liquids with sucralose in them,” says Sven Jordt, a toxicologist at Duke University School of Medicine who was not involved with the study.