“Here, we demonstrate that a high-sucrose diet during adolescence induces psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1 (GLO1), an enzyme involved in detoxification of sucrose metabolites. Furthermore, the high-sucrose diet induced microcapillary impairments and reduced brain glucose uptake in brains of Glo1-deficient mice.”
“When a mother experiences an infection during pregnancy and her immune system produces elevated levels of the molecule Interleukin-17a (IL-17a), that can not only alter brain development in her fetus, but also alter her microbiome such that after birth the newborn’s immune system can become primed for future inflammatory attacks.”
A joint research team at the Division of Biotechnology, DGIST, confirmed that microplastics(MPs) ingested orally accumulate in the brain and act as neurotoxic substances.
“The salt-tolerant fungus Debaryomyces hansenii, used in the food industry for surface ripening cheese and meat products, is enriched in the inflamed mucosal tissues of patients with Crohn’s disease and leads to impaired wound healing in mice”
New clinical research indicates that a widely used food additive, carboxymethylcellulose, alters the intestinal environment of healthy persons, perturbing levels of beneficial bacteria and nutrients.
Phthalate and novel plasticizer concentrations in food items from U.S. fast food chains: a preliminary analysis
“… these are the first measurements of DEHT in food. Our preliminary findings suggest that ortho-phthalates remain ubiquitous and replacement plasticizers may be abundant in fast food meals.”
“In RCTs examining cardiovascular outcomes, marine omega-3 supplementation was associated with an increased risk of AF. The risk appeared to be greater in trials testing >1g/d.”
Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression
Exposing newborn mice to low-dose penicillin led to substantial changes in intestinal microbiota population structure and composition. Transcriptomic alterations implicate pathways perturbed in neurodevelopmental and neuropsychiatric disorders. There also were substantial effects on frontal cortex and amygdala gene expression by bioinformatic interrogation, affecting multiple pathways underlying neurodevelopment.
“we have obtained brain tissues from a Colombian cohort of donors with familial Alzheimer’s disease. We have used established methods to measure the aluminum content of these tissues and we have compared the data with a recently measured dataset for control brain tissues. We report significantly higher levels of aluminum in brain tissues in donors […]
Researchers at Johns Hopkins found evidence of rises in the bloodstream levels of toxicants known to be stored long term in fat, including PCBs & organochlorine pesticides.