Blood-brain barrier breakdown is an early biomarker for human cognitive dysfunction (2019)

Posted on by ContraReport

Our data show that individuals with early cognitive dysfunction develop brain capillary damage and BBB breakdown in the hippocampus irrespective of Alzheimer’s Aβ and/or tau biomarker changes, suggesting that BBB breakdown is an early biomarker of human cognitive dysfunction independent of Aβ and tau.

Read Nature paper.

Nation, D.A., Sweeney, M.D., Montagne, A. et al. Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med 25, 270–276 (2019). https://doi.org/10.1038/s41591-018-0297-y

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