Here we discuss how the gut bacterial composition is altered in, and can contribute to, cardiometabolic disease, as well as how the gut bacteria can be targeted to treat and prevent metabolic diseases.
“It is extraordinary to discover that bacterial fragments act directly on a brain center as strategic as the hypothalamus, which is known to manage vital functions such as body temperature, reproduction, hunger and thirst,” comments Pierre-Marie Lledo, CNRS scientist and Head of the Institut Pasteur’s Perception and Memory Unit.”
“Lactobacillus—a type of bacteria thought to promote gut health—can alter the function of immune cells called macrophages in the pancreatic tumor environment and spur cancer growth, the researchers found”
Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database
“Our findings suggest antibiotics may have a role in colon tumour formation across all age-groups.”
“When a mother experiences an infection during pregnancy and her immune system produces elevated levels of the molecule Interleukin-17a (IL-17a), that can not only alter brain development in her fetus, but also alter her microbiome such that after birth the newborn’s immune system can become primed for future inflammatory attacks.”
“The salt-tolerant fungus Debaryomyces hansenii, used in the food industry for surface ripening cheese and meat products, is enriched in the inflamed mucosal tissues of patients with Crohn’s disease and leads to impaired wound healing in mice”
New clinical research indicates that a widely used food additive, carboxymethylcellulose, alters the intestinal environment of healthy persons, perturbing levels of beneficial bacteria and nutrients.
“New research (from University of Washington School of Medicine) suggests that the presence of certain bacteria in a gut biome may be an indicator of colon polyps that will become cancerous.”
“Here we show that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide (HMO) utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life”
“Conducting fecal microbial transplants from young mice to old mice, researchers were able to show a reversal of aging-associated differences and a slowing of cognitive impairments.”