“Here we show that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide (HMO) utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life”
“Conducting fecal microbial transplants from young mice to old mice, researchers were able to show a reversal of aging-associated differences and a slowing of cognitive impairments.”
Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression
Exposing newborn mice to low-dose penicillin led to substantial changes in intestinal microbiota population structure and composition. Transcriptomic alterations implicate pathways perturbed in neurodevelopmental and neuropsychiatric disorders. There also were substantial effects on frontal cortex and amygdala gene expression by bioinformatic interrogation, affecting multiple pathways underlying neurodevelopment.
A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases
“The lack of a comprehensive database for human-associated viruses has historically stymied efforts to interrogate the impact of the virome on human health. This study probes thousands of datasets to uncover sequences from over 45,000 unique virus taxa, with historically high per-genome completeness. Large publicly available case-control studies are reanalyzed, and over 2,200 strong virus–disease […]
“Many studies have revealed the involvement of mitochondrial stress in the pathophysiology of IBD but whether this is a cause or consequence of the disease is not known,”
“In chronic lung diseases and respiratory infections, alternations in the composition of the intestinal and airway microbiota are presented, commonly presenting as an outgrowth of Proteobacteria and Firmicutes. A vital cross-talk between these two compartments has been noted in the setting of lung diseases. This gut–lung axis allows for the passage of endotoxins, microbial metabolites, […]
“we have obtained brain tissues from a Colombian cohort of donors with familial Alzheimer’s disease. We have used established methods to measure the aluminum content of these tissues and we have compared the data with a recently measured dataset for control brain tissues. We report significantly higher levels of aluminum in brain tissues in donors […]
“A link between fecal dysbiosis (an imbalance in gut bacteria composition) and the genetic and epigenetic DNA signature in the animals’ tissues was identified using statistical tests. Mice who had received fresh stools from patients with sporadic colorectal cancer developed precancerous lesions”
Researchers at Johns Hopkins found evidence of rises in the bloodstream levels of toxicants known to be stored long term in fat, including PCBs & organochlorine pesticides.
“It isn’t only a story of ‘[metal] exposure leads to bad outcomes’ — it’s also a story of how different metabolic profiles may make certain people more vulnerable,”