“Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed […]
“A link between fecal dysbiosis (an imbalance in gut bacteria composition) and the genetic and epigenetic DNA signature in the animals’ tissues was identified using statistical tests. Mice who had received fresh stools from patients with sporadic colorectal cancer developed precancerous lesions”
“a Marshall University team revealed that consumption of two ounces of walnuts a day for about two weeks significantly changed gene expression in confirmed breast cancers.”
The biologists found that hundreds of genes are adversely affected by mild traumatic brain injury, such as a concussion. These altered genes can later lead to Alzheimer’s, Parkinson’s and other diseases.
“researchers have demonstrated for the first time that the administration of even extremely low doses of an endocrine disruptor – in this case, an endogenous oestrogen – leads to epigenetic changes in a pregnant sow’s DNA.”
“Gut microbiota alter host histone acetylation and methylation in multiple tissues• Western diet suppresses microbiota-driven SCFA production and chromatin effects• SCFAs recapitulate microbiota-driven chromatin and transcriptional effects”
“Researchers have discovered that a powerful guardian gene known to protect against a variety of autoimmune diseases, including type 1 diabetes, is triggered by the bacteria in our gut. This finding offers a clue to the complex interaction between our genes, immune system and gut microbiota.”
“Observations indicate that although atrazine does not promote disease in the directly exposed F1 [first] generation, it does have the capacity to promote the epigenetic transgenerational inheritance of disease in subsequent generations,” the researchers write.
“research suggests that altering aspects of the nutritional, microbial and psychosocial environment early in development can leave lasting marks on the epigenome, with the potential to reduce levels of chronic inflammation in adulthood.”
“Among the younger subjects who went through interval training, the activity levels had changed in 274 genes, compared with 170 genes for those who exercised more moderately and 74 for the weight lifters. Among the older cohort, almost 400 genes were working differently now, compared with 33 for the weight lifters and only 19 for […]