High-sucrose diets contribute to psychosis-related higher brain dysfunctions in mice

“Here, we demonstrate that a high-sucrose diet during adolescence induces psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1 (GLO1), an enzyme involved in detoxification of sucrose metabolites. Furthermore, the high-sucrose diet induced microcapillary impairments and reduced brain glucose uptake in brains of Glo1-deficient mice.”

Paper: DOI: 10.1126/sciadv.abl6077

Press Release: https://medicalxpress.com/news/2021-12-doesnt-excessive-intake-simple-sugar.html