Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression

Posted on by ContraReport

Exposing newborn mice to low-dose penicillin led to substantial changes in intestinal microbiota population structure and composition. Transcriptomic alterations implicate pathways perturbed in neurodevelopmental and neuropsychiatric disorders. There also were substantial effects on frontal cortex and amygdala gene expression by bioinformatic interrogation, affecting multiple pathways underlying neurodevelopment. 

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Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expressionVolkova, Angelina et al.iScience, Volume 24, Issue 7, 102797

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