A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases

“The lack of a comprehensive database for human-associated viruses has historically stymied efforts to interrogate the impact of the virome on human health. This study probes thousands of datasets to uncover sequences from over 45,000 unique virus taxa, with historically high per-genome completeness. Large publicly available case-control studies are reanalyzed, and over 2,200 strong virus–disease associations are found.”


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DOI: https://doi.org/10.1073/pnas.2023202118