Tag Archives: Alzheimers
Blood-brain barrier breakdown is an early biomarker for human cognitive dysfunction (2019)
Our data show that individuals with early cognitive dysfunction develop brain capillary damage and BBB breakdown in the hippocampus irrespective of Alzheimer’s Aβ and/or tau biomarker changes, suggesting that BBB breakdown is an early biomarker of human cognitive dysfunction independent of Aβ and tau.
Aluminum and Amyloid-β in Familial Alzheimer’s Disease
“we have obtained brain tissues from a Colombian cohort of donors with familial Alzheimer’s disease. We have used established methods to measure the aluminum content of these tissues and we have compared the data with a recently measured dataset for control brain tissues. We report significantly higher levels of aluminum in brain tissues in donors […]
UCLA cell study reveals how head injuries lead to serious brain diseases
The biologists found that hundreds of genes are adversely affected by mild traumatic brain injury, such as a concussion. These altered genes can later lead to Alzheimer’s, Parkinson’s and other diseases.
Studies show connection between diet, cognitive function
“…her data suggested that caloric restriction functioned as a sort of “fountain of youth” for aging rodents, whose neurovascular and metabolic functions were better than those of young mice on an unrestricted diet.”
Dietary fiber reduces brain inflammation during aging
“The new study reveals, in old mice, that butyrate inhibits production of damaging chemicals by inflamed microglia. One of those chemicals is interleukin-1β, which has been associated with Alzheimer’s disease in humans.”
Study shows how exercise generates new neurons, improves cognition in Alzheimer’s mouse
“A study by a Massachusetts General Hospital (MGH) research team finds that neurogenesis -inducing the production of new neurons – in the brain structure in which memories are encoded can improve cognitive function in a mouse model of Alzheimer’s disease.”
Canola oil linked to worsened memory and learning ability in Alzheimer’s
“a new study published online December 7 in the journal Scientific Reports by researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) associates the consumption of canola oil in the diet with worsened memory, worsened learning ability and weight gain in mice which model Alzheimer’s disease. The study is the first to […]
Landmark editorial identifies microbes as major cause of Alzheimer’s Disease
“A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes – a specific virus and two specific types of bacteria – are major causes of Alzheimer’s Disease.”
Green tea extract delivers molecular punch to disrupt formation of neurotoxic species
“Preclinical evidence suggests that the green tea compound known as EGCG interferes with the formation of toxic assemblies (oligomers), one of the prime suspects in the early steps of the molecular cascade that leads to cognitive decline in Alzheimer’s patients.”
More evidence shows natural plant compound may reduce mental effects of aging
“Salk scientists have found further evidence that a natural compound in strawberries reduces cognitive deficits and inflammation associated with aging in mice. The work, which appeared in the Journals of Gerontology Series A in June 2017, builds on the team’s previous research into the antioxidant fisetin, finding it could help treat age-related mental decline and […]