Monthly Archives: June 2016
Indicator of chronic fatigue syndrome found in gut bacteria
“Our work demonstrates that the gut bacterial microbiome in ME/CFS patients isn’t normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease,” said Maureen Hanson, the Liberty Hyde Bailey Professor in the Department of Molecular Biology and Genetics and the paper’s senior author.”
Fetal BPA exposure in mice linked to estrogen-related diseases
“Researchers from Yale show that the genome is permanently altered in the uterus of mice that had been exposed to BPA during their fetal development. These changes were found to mainly affect genes that are regulated by estrogen and are implicated in the formation of estrogen-related diseases such as infertility, endometriosis, endometrial cancer, osteoporosis, prostate […]
A single species of gut bacteria can reverse autistic-like behavior in mice
“By adding this bacterial species back to the guts of affected mice, the researchers were able to reverse some of the mice’s behavioral deficits, which are reminiscent of symptoms of autism spectrum disorders (ASDs) in humans.”
Interaction between cytokines, cannabinoids and the nervous system (2010)
“The [endocannabinoid system (ES)] participates in the regulation of immune responses in the nervous system. Activation of the cannabinoid system is associated with therapeutic effects that may be mediated by the down-regulation of cytokine expression. Here we review the findings from studies on the reciprocal regulation of the immune and cannabinoid systems, which is based […]
The endocannabinoid system: A revolving plate in neuro-immune interaction in health and disease (2012)
” Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are modulated by these agents, thus raising the hypothesis that these compounds may be of value in the management of chronic inflammatory diseases. The special properties of endocannabinoids as neurotransmitters, their pleiotropic effects and the impact on […]
Cannabinoids and the immune system: an overview (2010)
“Cannabinoids can modulate immune reactions in the periphery but also in the brain, influence T cell subset balance and cytokine expression and play a role in the balance between neuroinflammation and neurodegeneration. Immune cells can synthesize endocannabinoids and also be influenced by cannabinoid analogues.” Tanasescu, R., & Constantinescu, C. S. (2010). Cannabinoids and the immune […]
Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis (1989)
“as THC has been shown to inhibit both clinical and histologic [experimental autoimmune encephalomyelitis], it may prove to be a new and relatively innocuous agent for the treatment of immune-mediated diseases.” Lyman, W. D., Sonett, J. R., Brosnan, C. F., Elkin, R., & Bornstein, M. B. (1989). Δ9-Tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. […]
Cannabinoids as novel anti-inflammatory drugs (2009)
“It is becoming increasingly clear that cannabinoid receptors and their endogenous ligands play a crucial role in the regulation of the immune system. Exogenous cannabinoids have been shown to suppress T-cell-mediated immune responses by primarily inducing apoptosis and suppressing inflammatory cytokines and chemokines.” Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, […]
Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? (2011)
“Cannabinoids can modulate both the function and secretion of cytokines from immune cells. Therefore, cannabinoids may be considered for treatment of inflammatory disease.” Kozela, E., Lev, N., Kaushansky, N., Eilam, R., Rimmerman, N., Levy, R., … Vogel, Z. (2011). Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 […]
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation (2011)
“Treatment with CBD during disease onset ameliorated the severity of the clinical signs of [experimental autoimmune encephalomyelitis]. This effect of CBD was accompanied by diminished axonal damage and inflammation as well as microglial activation and T-cell recruitment in the spinal cord of MOG-injected mice. Moreover, CBD inhibited MOG-induced T-cell proliferation in vitro at both low […]