“The [endocannabinoid system (ES)] participates in the regulation of immune responses in the nervous system. Activation of the cannabinoid system is associated with therapeutic effects that may be mediated by the down-regulation of cytokine expression. Here we review the findings from studies on the reciprocal regulation of the immune and cannabinoid systems, which is based on functional as well as anatomical connections. We then discuss mechanisms involved in the reciprocal regulation of cytokines and the ES.”
Jean-Gilles, L., Gran, B., & Constantinescu, C. S. (2010). Interaction between cytokines, cannabinoids and the nervous system. Immunobiology, 215(8), 606-610. doi:10.1016/j.imbio.2009.12.006