“Here, we demonstrate that a high-sucrose diet during adolescence induces psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1 […]
Tag: Neuro
Research finds potential mechanism linking autism, intestinal inflammation
“When a mother experiences an infection during pregnancy and her immune system produces elevated levels of the molecule Interleukin-17a (IL-17a), that can not only alter brain development in her fetus, […]
Identification of a choroid plexus vascular barrier closing during intestinal inflammation
“The inflammatory process causes the gut vascular barrier to become more permeable, resulting in the spread of inflammation beyond the intestine, while the vascular barrier in the choroid plexus shuts […]
Effects of early-life penicillin exposure on the gut microbiome and frontal cortex and amygdala gene expression
Exposing newborn mice to low-dose penicillin led to substantial changes in intestinal microbiota population structure and composition. Transcriptomic alterations implicate pathways perturbed in neurodevelopmental and neuropsychiatric disorders. There also were […]
The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes
“Here, we summarize recent studies investigating the crosstalk between gut-innervating neurons, resident immune cells, and epithelial cells at homeostasis and during infection, food allergy, and inflammatory bowel disease.”
Aluminum and Amyloid-β in Familial Alzheimer’s Disease
“we have obtained brain tissues from a Colombian cohort of donors with familial Alzheimer’s disease. We have used established methods to measure the aluminum content of these tissues and we […]
Metals in Baby Teeth Could Help Reveal What Causes Autism, ADHD
“It isn’t only a story of ‘[metal] exposure leads to bad outcomes’ — it’s also a story of how different metabolic profiles may make certain people more vulnerable,”
Processed Foods May Hold Key to Rise in Autism
“the UCF scientists discovered how high levels of Propionic Acid (PPA), used to increase the shelf life of packaged foods and inhibit mold in commercially processed cheese and bread, reduce […]
Immune cells destroy healthy brain connections, diminish cognitive function in obese mice
“Obesity leads to cognitive impairment by activating microglial cells, which consume otherwise functional synapses in the hippocampus, according to a study of male mice published in JNeurosci.”
Studies show connection between diet, cognitive function
“…her data suggested that caloric restriction functioned as a sort of “fountain of youth” for aging rodents, whose neurovascular and metabolic functions were better than those of young mice on […]