“Our findings suggest that MS patients’ gut bacteria produce and release large amounts p-cresol-sulfate, indoxyl-sulfate and N-phenylacetylglutamine into the bloodstream, and they eventually reach the cerebrospinal fluid,” said Hye-Jin Park, one of the lead authors on the study and a research associate with the Neuroscience Initiative at the Advanced Science Research Center at the Graduate Center, CUNY (CUNY ASRC) “Once there, these toxic metabolites bathe the brain and spinal cord, and potentially play a role in the destruction of the myelin sheath that protect nerves.”
Read Eureka Alert press release (Dec 2021) here: https://www.eurekalert.org/news-releases/938603
Read paper published in Brain here: https://academic.oup.com/brain/article-abstract/145/2/569/6459638?redirectedFrom=fulltext
Achilles Ntranos, Hye-Jin Park, Maureen Wentling, Vladimir Tolstikov, Mario Amatruda, Benjamin Inbar, Seunghee Kim-Schulze, Carol Frazier, Judy Button, Michael A Kiebish, Fred Lublin, Keith Edwards, Patrizia Casaccia, Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma, Brain, Volume 145, Issue 2, February 2022, Pages 569–583, https://doi.org/10.1093/brain/awab320