Tag Archives: Multiple Sclerosis
Study identifies how Epstein-Barr virus triggers multiple sclerosis
“Part of the EBV protein mimics your own host protein—in this case, GlialCAM, found in the insulating sheath on nerves,” said William Robinson, MD, Ph.D., professor of immunology and rheumatology at Stanford. “This means that when the immune system attacks EBV to clear the virus, it also ends up targeting GlialCAM in the myelin.”
Vitamin D, Epstein-Barr virus, and endogenous retroviruses in multiple sclerosis – facts and hypotheses (2021)
“Here, we summarize the important data on vitamin D, including polymorphisms in genes related to vitamin D metabolism, EBV and ERV, in the pathogenesis of MS and create hypotheses regarding their interactions. Data indicate that vitamin D has a strong impact on viral infections and interferes with EBV infection, while EBV is capable of activating […]
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
“The team analyzed serum samples taken biennially by the military and determined the soldiers’ EBV status at time of first sample and the relationship between EBV infection and MS onset during the period of active duty. In this cohort, the risk of MS increased 32-fold after infection with EBV”
Mouse Study Reveals Subset of Immune Cells May Promote Inflammation in Multiple Sclerosis
“Collectively, our data define a population of inflammatory ILC3s that is essential for directly promoting T-cell-dependent neuroinflammation in the CNS and reveal the potential of harnessing peripheral tissue-resident ILC3s for the prevention of autoimmune disease,” concluded the researchers.
Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering Microbiota
“Intermittent fasting increases gut microbial diversity, alters their composition and metabolic pathways”
Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease
“Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.”
Resistance training may slow down the progression of multiple sclerosis
“Prior to and following the six-month period, the test subjects had their brains MR-scanned, and the researchers could see that there was a tendency for the brain to shrink less in those patients who undertook resistance training.”
Patients with multiple sclerosis may benefit from over-the-counter therapy
“an OHSU pilot study suggests over-the-counter antioxidant lipoic acid holds promise in improving patients’ lives.”
Nonpharmacologic Intervention Improves Mood and Cognitive Function in People with Multiple Sclerosis
“A modified Paleolithic diet, exercise, EStim, and stress management intervention like this one has the potential to improve the mood and cognitive symptoms that can lead to considerable suffering in people with MS, potentially improving quality of life and function for people with progressive MS.”
Brain microbiota disruption within demyelinating lesions in MS
“inflammatory demyelination is linked to an organ-specific dysbiosis in MS that could contribute to underlying disease mechanisms.”