Tag Archives: Multiple Sclerosis
The role of the gut microbiota in multiple sclerosis
“In this Review, we examine the influence that the gut microbiota have on immune function via modulation of serotonin production in the gut and through complex interactions with components of the immune system, such as T cells and B cells. We then present evidence from studies in mice and humans that these effects of the […]
Scientists identify gut-derived metabolites that play a role in neurodegeneration (2021)
“Our findings suggest that MS patients’ gut bacteria produce and release large amounts p-cresol-sulfate, indoxyl-sulfate and N-phenylacetylglutamine into the bloodstream, and they eventually reach the cerebrospinal fluid,” said Hye-Jin Park, one of the lead authors on the study and a research associate with the Neuroscience Initiative at the Advanced Science Research Center at the Graduate […]
Study identifies how Epstein-Barr virus triggers multiple sclerosis
“Part of the EBV protein mimics your own host protein—in this case, GlialCAM, found in the insulating sheath on nerves,” said William Robinson, MD, Ph.D., professor of immunology and rheumatology at Stanford. “This means that when the immune system attacks EBV to clear the virus, it also ends up targeting GlialCAM in the myelin.”
Vitamin D, Epstein-Barr virus, and endogenous retroviruses in multiple sclerosis – facts and hypotheses (2021)
“Here, we summarize the important data on vitamin D, including polymorphisms in genes related to vitamin D metabolism, EBV and ERV, in the pathogenesis of MS and create hypotheses regarding their interactions. Data indicate that vitamin D has a strong impact on viral infections and interferes with EBV infection, while EBV is capable of activating […]
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
“The team analyzed serum samples taken biennially by the military and determined the soldiers’ EBV status at time of first sample and the relationship between EBV infection and MS onset during the period of active duty. In this cohort, the risk of MS increased 32-fold after infection with EBV”
Mouse Study Reveals Subset of Immune Cells May Promote Inflammation in Multiple Sclerosis
“Collectively, our data define a population of inflammatory ILC3s that is essential for directly promoting T-cell-dependent neuroinflammation in the CNS and reveal the potential of harnessing peripheral tissue-resident ILC3s for the prevention of autoimmune disease,” concluded the researchers.
Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering Microbiota
“Intermittent fasting increases gut microbial diversity, alters their composition and metabolic pathways”
Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease
“Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.”
Resistance training may slow down the progression of multiple sclerosis
“Prior to and following the six-month period, the test subjects had their brains MR-scanned, and the researchers could see that there was a tendency for the brain to shrink less in those patients who undertook resistance training.”
Patients with multiple sclerosis may benefit from over-the-counter therapy
“an OHSU pilot study suggests over-the-counter antioxidant lipoic acid holds promise in improving patients’ lives.”