“our data allow us to propose a new adaptive mechanism involving the mitophagy protein BNIP3, which links mitochondrial and lysosomal homeostasis with inflammation and is key to maintaining muscle health during aging.”
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Irazoki, A., Martinez-Vicente, M., Aparicio, P., Aris, C., Alibakhshi, E., Rubio-Valera, M., Castellanos, J., Lores, L., Palacín, M., Gumà, A., Zorzano, A., & Sebastián, D. (2022). Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging. Aging Cell, 21, e13583. https://doi.org/10.1111/acel.13583