Tag Archives: MS
Brain microbiota disruption within demyelinating lesions in MS
“inflammatory demyelination is linked to an organ-specific dysbiosis in MS that could contribute to underlying disease mechanisms.”
Microbe changes in patients with multiple sclerosis found
“A team of researchers with Brigham and Women’s Hospital at Harvard Medical School has discovered that people with multiple sclerosis appear to have differences in their gut biome than the rest of the population.”
The endocannabinoid system: A revolving plate in neuro-immune interaction in health and disease (2012)
” Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are modulated by these agents, thus raising the hypothesis that these compounds may be of value in the management of chronic inflammatory diseases. The special properties of endocannabinoids as neurotransmitters, their pleiotropic effects and the impact on […]
Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis (1989)
“as THC has been shown to inhibit both clinical and histologic [experimental autoimmune encephalomyelitis], it may prove to be a new and relatively innocuous agent for the treatment of immune-mediated diseases.” Lyman, W. D., Sonett, J. R., Brosnan, C. F., Elkin, R., & Bornstein, M. B. (1989). Δ9-Tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. […]
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation (2011)
“Treatment with CBD during disease onset ameliorated the severity of the clinical signs of [experimental autoimmune encephalomyelitis]. This effect of CBD was accompanied by diminished axonal damage and inflammation as well as microglial activation and T-cell recruitment in the spinal cord of MOG-injected mice. Moreover, CBD inhibited MOG-induced T-cell proliferation in vitro at both low […]
Cannabinoids Decrease the Th17 Inflammatory Autoimmune Phenotype (2013)
“Here we show that the main psychoactive cannabinoid, Δ-9-tetrahydrocannabinol (THC), and the main nonpsychoactive cannabinoid, cannabidiol (CBD), markedly reduce the Th17 phenotype which is known to be increased in inflammatory autoimmune pathologies such as Multiple Sclerosis.” Kozela, E., Juknat, A., Kaushansky, N., Rimmerman, N., Ben-Nun, A., & Vogel, Z. (2013). Cannabinoids Decrease the Th17 Inflammatory […]
Fasting-like diet reduces multiple sclerosis symptoms
“During the fasting-mimicking diet, cortisone is produced and that initiates a killing of autoimmune cells,” said Valter Longo, the study’s lead author and professor who directs the USC Longevity Institute at the Davis School of Gerontology. “This process also leads to the production of new healthy cells.”
MS Microbiome Connection
“New research by investigators at Brigham and Women’s Hospital (BWH) suggests that bacteria living in the gut may remotely influence the activity of cells in the brain that are involved in controlling inflammation and neurodegeneration.”