“The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA. This is the result of a large-scale international study coordinated by Helmholtz Zentrum München, a partner in the German Center for Diabetes Research, which has now been published in ‘Nature‘. The study shows that a high BMI leads to epigenetic changes at nearly 200 loci of the genome – with effects on gene expression.”
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 2016; DOI: 10.1038/nature20784