“early postnatal mice exposed to isoflurane – a standard and widely used inhaled general anesthetic agent – leads to chronic, abnormal activation of the mTOR pathway, a signaling system critical for normal brain development.”
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Kang E, Jiang D, Ryu YK, Lim S, Kwak M, Gray CD, et al. (2017) Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway. PLoS Biol 15(7): e2001246. doi.org/10.1371/journal.pbio.2001246