Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.
Huypens, P., Sass, S., Wu, M. et al. Epigenetic germline inheritance of diet-induced obesity and insulin resistance. Nat Genet 48, 497–499 (2016). https://doi.org/10.1038/ng.3527
