“Researchers have singled out a bacterial enzyme behind an imbalance in the gut microbiome linked to Crohn’s disease. The new study suggests that wiping out a significant portion of the bacteria in the gut microbiome, and then re-introducing a certain type of ‘good’ bacteria that lacks this enzyme, known as urease, may be an effective approach to better treat these diseases.”
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Journal Reference:
- Josephine Ni, Ting-Chin David Shen, Eric Z. Chen, Kyle Bittinger, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S. Friedman, Lillian Chau, Andrew Lin, Ilana Nissim, Justin Scott, Abigail Lauder, Christopher Hoffmann, Gloriany Rivas, Lindsey Albenberg, Robert N. Baldassano, Jonathan Braun, Ramnik J. Xavier, Clary B. Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D. Bushman, James D. Lewis, Gary D. Wu. A role for bacterial urease in gut dysbiosis and Crohn’s disease. Science Translational Medicine, 2017; 9 (416): eaah6888 DOI: 10.1126/scitranslmed.aah6888