Tag Archives: Crohns
Phages Treat Gut Inflammation in Mice
“Phase 2 clinical trial to evaluate the effectiveness of using a phage mixture to treat IBD in humans has been approved but not yet started, says Elinav, who cofounded a company seeking to commercialize phage treatments. The study authors conclude that in addition to the prospect of leading to a generalized therapy, their results indicate […]
Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice
“The salt-tolerant fungus Debaryomyces hansenii, used in the food industry for surface ripening cheese and meat products, is enriched in the inflamed mucosal tissues of patients with Crohn’s disease and leads to impaired wound healing in mice”
Mitochondrial dysfunction in Crohn’s disease
“Many studies have revealed the involvement of mitochondrial stress in the pathophysiology of IBD but whether this is a cause or consequence of the disease is not known,”
A comparative study of the gut microbiota in immune-mediated inflammatory diseases
“new study has found some common gut microbiota taxa patterns in Crohn’s disease, ulcerative colitis, multiple sclerosis & rheumatoid arthritis” Read more here.
Vit D leads to a shift of the bacterial composition in Crohn’s disease
“Vitamin D has a specific influence on the bacterial communities in CD, but not in healthy controls.”
Engineering the gut microbiome with ‘good’ bacteria may help treat Crohn’s disease
“Researchers have singled out a bacterial enzyme behind an imbalance in the gut microbiome linked to Crohn’s disease. The new study suggests that wiping out a significant portion of the bacteria in the gut microbiome, and then re-introducing a certain type of ‘good’ bacteria that lacks this enzyme, known as urease, may be an effective […]
Two distinct metacommunities characterize the gut microbiota in Crohn’s disease patients
“The microbiotas in CD patients can be stratified into 2 distinct metacommunities, with the most severely perturbed metacommunity exhibiting functional potentials that deviate markedly from that of the healthy individuals, with possible implication in relation to CD pathogenesis.”
STUDY: Diet induced clinical improvement in IBD
Study Conclusion: “SCD therapy in IBD is associated with clinical and laboratory improvements as well as concomitant changes in the fecal microbiome.” [1] “Suskind suspects that IBD is caused when the immune system reacts to unhealthy bacteria in the microbiome – the bacterial community in the gut and intestine. He hypothesizes that the SCD feeds […]
Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study (2013)
“a short course (8 weeks) of THC-rich cannabis produced significant clinical, steroid-free benefits to 10 of 11 patients with active Crohn’s disease, compared with placebo, without side effects.” Naftali, T., Schleider, L. B., Dotan, I., Lansky, E. P., Benjaminov, F. S., & Konikoff, F. M. (2013). Cannabis Induces a Clinical Response in Patients With Crohn’s […]
Lab team spins ginger into nanoparticles to heal inflammatory bowel disease
“The advantage of ginger, say the researchers, is that it’s nontoxic, and could represent a very cost-effective source of medicine. “