“As opposed to the normal process of gradually linking up different centers in the brain after a stimulus, chronic pain patients have conditions that predispose them to linking up in an abrupt, explosive manner,”
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UnCheol Lee, Minkyung Kim, KyoungEun Lee, Chelsea M. Kaplan, Daniel J. Clauw, Seunghwan Kim, George A. Mashour, Richard E. Harris. Functional Brain Network Mechanism of Hypersensitivity in Chronic Pain. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-017-18657-4