“researchers have demonstrated for the first time that the administration of even extremely low doses of an endocrine disruptor – in this case, an endogenous oestrogen – leads to epigenetic changes in a pregnant sow’s DNA.”
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Vera A. van der Weijden, Veronika L. Flöter, Susanne E. Ulbrich. Gestational oral low-dose estradiol-17β induces altered DNA methylation of CDKN2D and PSAT1 in embryos and adult offspring. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-25831-9