Monthly Archives: December 2021
“In this review, we have presented an updated prospective of the mitochondrial machinery that drives various immune responses.”
“Here, we demonstrate that a high-sucrose diet during adolescence induces psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1 (GLO1), an enzyme involved in detoxification of sucrose metabolites. Furthermore, the high-sucrose diet induced microcapillary impairments and reduced brain glucose uptake in brains of Glo1-deficient mice.”
“When a mother experiences an infection during pregnancy and her immune system produces elevated levels of the molecule Interleukin-17a (IL-17a), that can not only alter brain development in her fetus, but also alter her microbiome such that after birth the newborn’s immune system can become primed for future inflammatory attacks.”
A joint research team at the Division of Biotechnology, DGIST, confirmed that microplastics(MPs) ingested orally accumulate in the brain and act as neurotoxic substances.
“The salt-tolerant fungus Debaryomyces hansenii, used in the food industry for surface ripening cheese and meat products, is enriched in the inflamed mucosal tissues of patients with Crohn’s disease and leads to impaired wound healing in mice”
“Collectively, our data define a population of inflammatory ILC3s that is essential for directly promoting T-cell-dependent neuroinflammation in the CNS and reveal the potential of harnessing peripheral tissue-resident ILC3s for the prevention of autoimmune disease,” concluded the researchers.
“Our work demonstrates a mechanism by which vitamin D reduces inflammation caused by T cells. These are important cells of the immune system and implicated as part of the immune response to the infection causing COVID-19.”
Updated Dec 10, 2021 3 DEC 2020: Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host (NEJM)“Phylogenetic analysis was consistent with persistent infection and accelerated viral evolution. Amino acid changes were predominantly in the spike gene and the receptor-binding domain, which make up 13% and 2%” 5 FEB 2021: SARS-CoV-2 evolution during treatment of chronic […]