“The team has created a sophisticated metallocyclic complex using platinum that has not only enabled curcumin’s solubility, but whose synergy has proven 100 times more effective in treating various cancer types such as melanoma and breast cancer cells than using curcumin and platinum agents separately.”
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Sougata Datta, Santosh K. Misra, Manik Lal Saha, Nabajit Lahiri, Janis Louie, Dipanjan Pan, Peter J. Stang. Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells. Proceedings of the National Academy of Sciences, 2018; 201803800 DOI: 10.1073/pnas.1803800115