“In this study, researchers found an association with use of the drug and lower levels of “sulfated” forms of sex hormones in men and women. Also called neurosteroids, many of these hormones are active in the brain. One of these hormones, DHEA-S, is well known to be important for placental health.”
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Paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC5835573/
Cohen IV, Cirulli ET, Mitchell MW, Jonsson TJ, Yu J, Shah N, Spector TD, Guo L, Venter JC, Telenti A. Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones. EBioMedicine. 2018 Feb;28:316-323. doi: 10.1016/j.ebiom.2018.01.033. Epub 2018 Feb 15. PMID: 29398597; PMCID: PMC5835573.