“Researchers examined identical twins–one afflicted with familial ALS and one not–and found that environmental factors were likely necessary to alter the expression of some immune genes (epigenetic changes) before the disease could take hold.”
Read press release here.
L. Lam, L. Chin, R. C. Halder, B. Sagong, S. Famenini, J. Sayre, D. Montoya, L. Rubbi, M. Pellegrini, M. Fiala. Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients. The FASEB Journal, 2016; DOI: 10.1096/fj.201600259RR