(preprint) “We conclude that ME/CFS is accompanied by substantial and measurable changes in coagulability, platelet hyperactivation, and fibrinaloid microclot formation. … Fibrinaloid microclots, in particular can provide a ready explanation, […]
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Blood-brain barrier breakdown is an early biomarker for human cognitive dysfunction (2019)
Our data show that individuals with early cognitive dysfunction develop brain capillary damage and BBB breakdown in the hippocampus irrespective of Alzheimer’s Aβ and/or tau biomarker changes, suggesting that BBB […]
Sulforaphane exhibits antiviral activity against SARS-CoV-2 in vitro and in mice
“We determined that SFN has potent antiviral activity against HCoV-OC43 and multiple strains of SARS-CoV-2, including Delta and Omicron … “we documented that SFN can inhibit in vitro and in […]
The Metabolic Role and Therapeutic Potential of the Microbiome
Here we discuss how the gut bacterial composition is altered in, and can contribute to, cardiometabolic disease, as well as how the gut bacteria can be targeted to treat and […]
Decoding a direct dialog between the gut microbiota and the brain
“It is extraordinary to discover that bacterial fragments act directly on a brain center as strategic as the hypothalamus, which is known to manage vital functions such as body temperature, […]
How zinc boosts the immune system
In mice, mineral improves regeneration of key immune organ and immune-cell recovery after bone marrow transplant
Coordination of mitochondrial and lysosomal homeostasis mitigates muscle atrophy during aging
“our data allow us to propose a new adaptive mechanism involving the mitophagy protein BNIP3, which links mitochondrial and lysosomal homeostasis with inflammation and is key to maintaining muscle health […]
Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber
“A new type of ultraviolet light that is safe for people took less than five minutes to reduce the level of indoor airborne microbes by more than 98%, a joint […]
Study identifies how Epstein-Barr virus triggers multiple sclerosis
“Part of the EBV protein mimics your own host protein—in this case, GlialCAM, found in the insulating sheath on nerves,” said William Robinson, MD, Ph.D., professor of immunology and rheumatology […]